The PP2A alpha / beta Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated from Bioss Inc. is a Rabbit Polyclonal antibody to PPP2CA. This antibody recognizes Human, and Mouse antigen. The PP2A alpha / beta Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated has been validated for the following applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry - fixed, and Immunohistochemistry - frozen.
Description
PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV4 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'